(426) Effect of naldemedine, a peripherally acting μ-opioid receptor antagonist, on QT interval
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منابع مشابه
Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus.
574 P&T® • October 2008 • Vol. 33 No. 10 INTRODUCTION In 2007, Goldstein et al. sought to determine the economic burden attributed to the management of postoperative ileus (POI) associated with abdominal surgery in the U.S. Their study revealed an annual national hospital cost of $1.46 billion for both the index hospitalization and any readmissions within 30 days. POI is one of the expected com...
متن کاملPeripherally acting μ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy
Opioid-induced constipation (OIC), a prevalent and distressing side effect of opioid therapy, does not reliably respond to treatment with conventional laxatives. OIC can be a treatment-limiting adverse event. Recent advances in medications with peripherally acting μ-opioid receptor antagonists, such as methylnaltrexone, naloxegol, and alvimopan, hold promise for treating OIC and thus extending ...
متن کاملPharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation
Opioid-induced constipation (OIC) is a common side effect of opioid pharmacotherapy for the management of pain because opioid agonists bind to µ-opioid receptors in the enteric nervous system (ENS). Naloxegol, a polyethylene glycol derivative of naloxol, which is a derivative of naloxone and a peripherally acting µ-opioid receptor antagonist, targets the physiologic mechanisms that cause OIC. P...
متن کاملAlvimopan: a peripheral acting μ-opioid-receptor antagonist used for the treatment of postoperative ileus
Louis Balsama1 & James Weese2† †Author for correspondence 1University of Medicine and Dentistry of New Jersey– School of Osteopathic Medicine (UMDNJ-SOM), Suite 2500 University Doctors Pavilion, 42 E. Laurel Rd, Stratford, NJ 08084, USA 2University of Medicine and Dentistry of New Jersey– School of Osteopathic Medicine (UMDNJ-SOM), Suite 2500 University Doctors Pavilion, 42 E. Laurel Rd, Stratf...
متن کاملMethylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells.
BACKGROUND Methylnaltrexone, a novel peripherally acting opioid receptor antagonist, is used to treat opiate-induced constipation in cancer patients. Its effects on the activities of chemotherapeutic agents, however, have not been evaluated. In this study, the effect of methylnaltrexone on the action of 5-fluorouracil (5-FU) was tested in three human cancer cell lines. MATERIALS AND METHODS T...
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ژورنال
عنوان ژورنال: The Journal of Pain
سال: 2016
ISSN: 1526-5900
DOI: 10.1016/j.jpain.2016.01.403